Pathological and Histochemical Alterations in the Small Intestine of Sheep in the Course of Experimental Infection with Strongyloides Papillosus

It was demonstrated that partogenetic Strongyloides papillosus females living in the small intestine of sheep infected with L3 S. papillosus larvae caused the necrosis of the mucosa and, in some cases, destruction of the intestinal villi. Furthermore, the enzymatic activity of the epithelial cells of the small intestine was strongly correlated with the morphological picture of the intestine. As early as 11 d after the infection a decrease in alkaline phosphatase in the epithelial cells, stroma and base of the villi was noted. A reduced activity of the enzyme in the epithelium was continued but in the stroma the reaction was negligible.